- Thomas Jennings, the first known African American to hold a patent, used the money he earned from his invention to fund abolitionist causes.
- Benjamin Banneker (1731-1806) Born into a family of free blacks in Maryland, Banneker learned the rudiments of reading, writing, and arithmetic from his grandmother and a Quaker schoolmaster. Later he taught himself advanced mathematics and astronomy. He is best known for publishing an almanac based on his astronomical calculations.
- Rebecca Cole (1846-1922) Born in Philadelphia, Pennsylvania, Cole was the second black woman to graduate from medical school (1867). She joined Dr. Elizabeth Blackwell, the first white woman physician, in New York and taught hygiene and childcare to families in poor neighborhoods.
- Edward Alexander Bouchet (1852-1918) Born in New Haven, Connecticut, Bouchet was the first African American to graduate (1874) from Yale College. In 1876, upon receiving his Ph.D. in physics from Yale, he became the first African American to earn a doctorate. Bouchet spent his career teaching college chemistry and physics.
- Dr. Daniel Hale Williams (1856-1931) Williams was born in Pennsylvania and attended medical school in Chicago, where he received his M.D. in 1883. He founded the Provident Hospital in Chicago in 1891, and he performed the first successful open heart surgery in 1893.
- George Washington Carver (1865-1943) Born into slavery in Missouri, Carver later earned degrees from Iowa Agricultural College. The director of agricultural research at the Tuskegee Institute from 1896 until his death, Carver developed hundreds of applications for farm products important to the economy of the South, including the peanut, sweet potato, soybean, and pecan.
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